THBS2 and hepatocellular carcinoma: We found that male gender, history of HCC and TSP2 High at SVR12 were independent factors associated with HCC occurrence after DAA treatment (male: HR 4.84, 95% CI 1.62–14.43, p = 0.005; HCC history: HR 4.61, 95% CI 1.31–16.17, p = 0.017; TSP2: HR 3.93, 95% CI 1.39–11.06, p = 0.009).