In Multivariate Model 2, where cirrhosis replaced FIB‐4 among the variables in model 1, male gender, history of HCC and High TSP2 at SVR12 remained independent factors for HCC development after DAA treatment (male: HR 4.09, 95% CI 1.40–11.89, p = 0.009; HCC history: HR 8.13, 95% CI 1.95–33.85, p = 0.004; TSP2: HR 3.64, 95% CI 1.24–10.63, p = 0.018). This evidence concerns the gene THBS2 and hepatocellular carcinoma.