We analyzed the experimental results of IHC and observed that the positive staining (brown area) of Ki-67, CKAP2, CD163, and CD31 was reduced after CKAP2 knockdown in the tumor tissues of mice, showing the inhibitory effects of CKAP2 knockdown on proliferation and angiogenesis of tumor cells (Fig. 7D). This evidence concerns the gene CKAP2 and neoplasm.