We analyzed the experimental results of IHC and observed that the positive staining (brown area) of Ki-67, CKAP2, CD163, and CD31 was reduced after CKAP2 knockdown in the tumor tissues of mice, showing the inhibitory effects of CKAP2 knockdown on proliferation and angiogenesis of tumor cells (Fig. 7D). The gene discussed is PECAM1; the disease is neoplasm.