PIK3R1 and hereditary pheochromocytoma-paraganglioma: We performed a pan-cancer analysis of PIK3R1 and YWHAZ which were statistically analyzed and visualized with R software based on data from the UCSC database (Fig. 1N), showing that PIK3R1 was significantly down-regulated in 15 types of tumors, such as bladder urothelial carcinoma and breast invasive carcinoma, and significantly up-regulated in pheochromocytoma and paraganglioma.