To address APC-related SL-based genetic interactions in CRC, SLOAD, a synthetic lethal gene prediction platform (http://www.tmliang.cn/SLOAD/),3 was used to screen APC-related interactions, and APC and cyclin-dependent kinase 9 (CDK9) were finally selected as a candidate gene pair with promising clinical application in personalized medicine. Here, CDK9 is linked to colorectal carcinoma.