This leads to the nuclear translocation of YBX1 and activation of genes such as fibroblast growth factor receptor 1 (FGFR1), tenascin-C (TNC) and neurotrophic tyrosine kinase receptor 1 (NTRK1), thereby promoting resistance to cisplatin in NPC[89]. The gene discussed is TNC; the disease is nasopharyngeal carcinoma.