Interestingly, PD-L1 depletion was also shown to increase the levels of IFN-γ and IL-4, but reduce IL-10 expression in the CD8+ T cells and the supernatants, suggesting that the NSCLC cells inactivated CD8+ T cells in the co-culture via secreting PD-L1[106]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.