Immune checkpoint blockade with anti-CTLA-4 (ipilimumab and tremelimumab), anti-PD-1 (nivolumab and pembrolizumab), or anti-PD-ligand (PD-L1) (durvalumab, atezolizumab, and avelumab) monoclonal antibodies is revolutionizing cancer therapy, which induces durable tumor responses and overall survival benefit in a wide variety of cancer types[92]. Here, CTLA4 is linked to cancer.