These differences are evident in ALS patients (McCombe and Henderson, 2010; Hou et al., 2019; Tang et al., 2019; Zamani et al., 2024) and ALS SOD1 mouse models (Heiman-Patterson et al., 2005; Alves et al., 2011; Pfohl et al., 2015). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.