In this study, we evaluated the respiratory function of transgenic Prp-hTDP-43A315T (will be further referred to as TDP-43 A315T mice), a mouse model of ALS and age/sex-matched wildtype (WT) each month, until the TDP-43 A315T mice reached their terminal stage (Wegorzewska et al., 2009). Here, TARDBP is linked to amyotrophic lateral sclerosis.