On the other hand, the amounts of six bacteria (Akkermansia muciniphila, Turicibacter, Thermicanus, Clostridium saccharogumia, Lactobacillus pontis, etc.)were upregulated, and that of Coprobacillus was downregulated, while soybean oil exhibited attenuate metabolic syndrome effect (67) against high-fat diet-induced mice and increase insulin sensitivity and prevent fatty liver activities in normal mice (68). Here, INS is linked to metabolic syndrome.