Flaxseed oil intervention modulated the microbial bile acids (BAs) metabolism in feces while exhibited anti-atherosclerosis action on high-fat diet-induced ApoE−/− mice, showing increases of lithocholic acid, allocholic acid, glycocholic acid, and taurocholic acid and decreases of allolithocholic acid, isolithocholic acid, 7-ketodeoxycholic acid, β-ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid (58). The gene discussed is APOE; the disease is atherosclerosis.