For flaxseed oil revealed anti-diabetes effect toward streptozotocin-nicotinamide-induced rats (55), Firmicutes was positively correlated with LPS, IL-1β, TNF-α, IL-6, and IL-17A, Bacteroidetes was negatively correlated with LPS, IL-1β, TNF-α, and IL-17A, Blautia was positively correlated with LPS, IL-1β, TNF-α, and IL-6, and Alistipes was negatively correlated with LPS and TNF-α. Here, TNF is linked to diabetes mellitus.