Linarine increased body weight and lowered body temperature in dry eye model mice, significantly prolonged tear film rupture time, promoted tear secretion, repaired corneal damage, and reduced the expression levels of inflammatory factors MAPK, NF-kB, JNK, IL-1β, and IL-18, thereby reducing the severity of inflammatory response. The gene discussed is IL18; the disease is Keratoconjunctivitis sicca.