One such example of vascular niche involvement was a study that has demonstrated CSC populations expressing CD133+ marker in brain, liver, and pancreatic cancers produce increased levels of vascular endothelial growth factor (VEGF) and stromal-derived factor-1 (SDF-1), which stimulate angiogenesis thereby promoting metastasis (73–75). The gene discussed is VEGFA; the disease is familial pancreatic carcinoma.