Accumulating evidence shows EMT is associated with many signaling pathways such as androgen receptor signaling, estrogen receptor signaling, TGF-β (transforming growth factor β) signaling, epidermal growth factor (EGF) signaling, Sonic hedgehog and WNT signaling pathways and its role in the related tissue development, wound healing and cancer (76, 77). This evidence concerns the gene EGF and cancer.