1) IFN-γ-related genes are associated with antigen presentation, cytotoxicity, and chemokines secretion;2) TAMs release CXCL5 to recruit MDSCs to TME via CXCR2-CXCL5 axis and release CCL18 to promote tumor proliferation via JAK2/STAT3 pathway;3) CCL19 activates MEK1-ERK1/2 and PI3K-AKT pathway in M1-TAMs by CCR7 to mediate their chemotaxis;4) CCL2-CCR2 axis mediates TAMs infiltration to affect PD-1 signaling in cancer cells, leading to their immune evasion. The gene discussed is MAP2K1; the disease is neoplasm.