1) Elevated glucocorticoid is associated with lower infiltration level of CD4+ T cells and CD8+ T cells, as well as higher NLR;2) More active glucocorticoid suppresses IFN-γ secretion from CD8+ T cells and curbs inflammatory state of TAMs;3) GR downregulates MHC-1 level of cancer cells and inhibits the infiltration of cytotoxic T cells. This evidence concerns the gene NR3C1 and cancer.