Chromosome 11q13 amplification consists of the amplification of miR-548k and CCND1:1) MiR-548k promotes lymphangiogenesis by ADAMTS1/VEGFC/VEGFR3 axis and facilitates nodal metastasis by LF10/EGFR pathway;2) CCND1 induces the exhaustion of anti-tumor immune cells and elevates the density of Ths, Tregs, MDSCs. This evidence concerns the gene FLT4 and neoplasm.