LAG3 and neoplasm: The researchers investigated the condition of tumor microenvironment (TME) in each of the samples, observing that the patients in S2 group had higher levels of Tregs, resting memory CD4+ T cells, Ths, macrophages and activated mast cells, as well as higher levels of immune checkpoint molecules, including CTLA-4 and lymphocyte activation gene-3 (LAG-3) (52).