NOD2 and colitis: Consistent with the data obtained from NOD2-deficient mice, NOD2-transgenic mice under the control of a major histocompatibility complex class II promoter, that is, mice overexpressing NOD2 in macrophages and DCs, were resistant to TLR2-dependent experimental colitis induced through the intrarectal administration of PGN when compared with wild-type mice (43).