The results of Sankey diagrams revealed that the cell groups in outgoing patterns were astrocytoma, Oligodendrocytes, Excitatory neuronal cells, Proliferating cells, Muller glia cells, Inhibitory neuronal cells and Pericytes send out signals in coordination with the signal paths PTN, MK and SPP1 belonging to pattern1 (Figure 5G). The gene discussed is SPP1; the disease is astrocytoma (excluding glioblastoma).