Consequentially, the levels of BMDCs STING, phospho-IRF3, and IFN-β were elevated, revealing that TPOM nanocomplex irradiation is a biocompatible and potent means of activating BMDC STING signalling through the release of tumour antigens and co-stimulatory adjuvant molecules (ovalbumin and Mn2+). This evidence concerns the gene STING1 and neoplasm.