Ultimately, NIR irradiation of the TPOM nanocomplex led to efficient release of Mn2+ ions, ovalbumin, and mt-DNA synergistically activated dendritic cell cGAS/STING, culminating in improved dendritic cell maturation, enhanced tumour antigen presentation, increased inflammatory cytokine release, and increased CD8+ cytotoxic T-lymphocyte recruitment and activation at both local and metastatic tumour sites. Here, CD8A is linked to neoplasm.