CD8A and neoplasm: Specifically, the cyclic GMP-AMP synthase/Stimulator of Interferon Genes (cGAS/STING) pathway is an emerging immunomodulatory node due to its role in type 1 interferon production and the upregulation of antigen presentation, dendritic cell maturation, and CD8+ T-lymphocyte-mediated tumour cell clearance (18–20).