In addition to the KEGG-annotated genes, we were interested in the expression of genes relevant to human adipose thermogenesis not yet annotated in the KEGG thermogenesis pathway, e.g. fat mass and obesity-associated gene FTO (FTO), associated AT-rich interaction domain 5B (ARID5B), iroquois homeobox 5 (IRX5), and iroquois homeobox 3 (IRX3) [67]. The gene discussed is IRX5; the disease is obesity due to melanocortin 4 receptor deficiency.