In addition to BRAF and Titin (TTN), Adenosine Deaminase 2 (ADA2), ATPase H+ Transporting V1 Subunit E1 (ATP6V1E1), BCL2 Like 13 (BCL2L13), BH3 Interacting Domain Death Agonist (BID), Cat Eye Syndrome Chromosome Region, Candidate 3 (CECR3), Cat Eye Syndrome Chromosome Region, Candidate 7 (CECR7), Haloacid Dehalogenase Like Hydrolase Domain Containing 5 (HDHD5), and HDHD5 Antisense RNA 1 (HDHD5-AS1), were exhibited the same mutation frequencies from altered genome fraction (Figure 1E). The gene discussed is TTN; the disease is cat-eye syndrome.