THY1 and Parkinson disease: (Sampson and Mazmanian, 2015) Additionally, a study involving Thy1-αSyn (ASO) mice showed that mice receiving faecal transplants from PD patients exhibited more severe motor deficits compared to those transplanted with healthy human faeces, indicating that alterations in the human microbiome could be a risk factor for PD (Sampson et al., 2016).