At a functional level, PRG5 is involved in the formation of filopodia in various cell types, including N1E-115 neuroblastoma, P19 carcinoma and HEK293T cells, as well as in the formation of plasma membrane protrusions in primary cortical and hippocampal neurons (Broggini et al., 2010; Gross et al., 2022b). This evidence concerns the gene PLPPR5 and neuroblastoma.