Single nucleotide polymorphisms (SNPs) with statistically significant association (p-value <0.05) to Parkinson ́s Disease (PD) for the genes of the four human cholesterol degrading cytochrome P450, CYP7B1, CYP27A1, CYP39A1 and CYP46A1. This evidence concerns the gene CYP46A1 and Parkinson disease.