LAMP2 and pancreatitis: Genetic modifications of core autophagy-related proteins like Atg5, Atg7, or LAMP2 in the pancreas lead to severe acinar cell degeneration, exocrine pancreas atrophy, fibrosis, inflammation, and cellular damage (Antonucci et al., 2015; Mareninova et al., 2015), highlighting autophagy impairment’s role in exacerbating pancreatitis severity.