NCAPD2 and early-onset autosomal dominant Alzheimer disease: In addition, a number of studies have demonstrated that NCAPD2 is linked to a number of neurodevelopmental diseases, including Alzheimer’s disease, autism, Parkinson’s disease, and others, which suggests that it may have a function in the development of the central nervous system (Lee et al., 2008; Li et al., 2009; Sanders et al., 2012; Zhang et al., 2014).