The lncRNA H19, which has oncogenic properties in colorectal cancer, mediates 5-fluorouracil resistance by sponging miR-194–5p to elevate SIRT1 expression, thus promoting autophagy-induced resistance to 5-fluorouracil in colorectal tumors (Wang et al., 2018). The gene discussed is SIRT1; the disease is colorectal neoplasm.