ORAI1 and Allergy: Phan et al. demonstrated that in vitro treatment of HEK293T cells and Calu-3 cells with magnolol inhibits ORAI1 (which causes T-lymphocyte and mast cell activation and initiates allergy) and anoctamin 1 (ANO1) (which causes mucin secretion and allergic inflammation) in HEK293T cells and chloride secretion in the Calu-3 cells also reduced IL-2 levels in T-lymphocytes.