IFNG and hypophosphatasia: We observed that AEA patients in LPP produced higher levels of both IFN-γ (Figure 8A) and IL-10 (Figure 8D) (IFN-γ median: 3,809 pg/ml, IL-10 median: 4,174 pg/ml) compared to those in HPP (IFN-γ median: 2,562 pg/ml, IL-10 median: 2,277 pg/ml).