Common genes mutated in CHIP and CCUS are: DNMT3A, TET2, ASXL1, JAK2, TP53, SF3B1, PPM1D, SRSF2, IDH1, IDH2, U2AF1, KRAS, NRAS, CTCF, CBL, GNB1, RUNX1, EZH2, PTPN11, etc. VEXAS syndrome is characterized by somatic UBA1 mutations. The gene discussed is IDH2; the disease is VEXAS syndrome.