Commonly genetic alterations in MDS include TET2, ASXL1, SF3B1, DNMT3A, SRSF2, del(5q), RUNX1, TP53, STAG2, complex karyotype, U2AF1, +8, EZH2, ZRSR2, BCOR, ‐Y, −7/del(7q), del(20q), DDX41, SAMD9, SAMD9L, etc. The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.