In other instances, the detection of a specific protein (e.g. p53 by IHC) or finding of a distinct, abnormal cytomorphologic alteration (e.g. numerous ring sideroblasts on iron stain in suspected MDS with low blasts and SF3B1 mutation) may provide helpful “nonmolecular” diagnostic information when interpreted appropriately. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.