Interestingly, the expression of T‐IC‐related markers such as EpCAM, CD24 and CD133 was significantly increased in MCB1‐TG mice and decreased in MCB1hep‐/− mice (Figure S2L,M, Supporting Information), suggesting that MCB1 gives rise to T‐ICs and drives HCC initiation. Here, EPCAM is linked to hepatocellular carcinoma.