Compared to those who did not have a MACE, bivariable analyses (see Table 1) showed that those who did were older, had a lower alcohol consumption, were more likely to be insulin-treated, had higher systolic blood pressure, were more likely to have had prior CVD (excluding MI and stroke), and had a higher likelihood of anaemia, retinopathy and PAD, and a greater uACR. This evidence concerns the gene INS and retinal disorder.