ACE2 and infection: Briefly, viral-induced organ damage mediated via initial viral entry through the interaction of SARS-CoV-2 with the angiotensin-converting enzyme 2 (ACE2) receptor found to be highly expressed in the lungs, heart, gastrointestinal tract, central/nervous system, and pancreas [49–51] is believed to be a major mechanism for leading to dysfunction of multiple different organs during the acute phase of infection.