Additionally, studies have shown that in cases of ADGRG2 mutations, proximal epididymal tissue lacks ADGRG2 protein expression, further indicating that the loss of ADGRG2 protein function due to ADGRG2 mutations is closely related to the occurrence of CBAVD [31]. Here, ADGRG2 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.