Cross-correlation of the quantifiable neuropathological variables followed by hierarchical clustering revealed eight biologically coherent clusters (Fig. 2c), with two anticorrelated clusters: cluster 3, which contained measurements of AD-related pathological proteins (that is, diameter of Aβ plaques, number of Aβ plaques or pTau-bearing cells); and cluster 7, which contained NeuN-ir in neuron-related variables (that is, the number of NeuN-ir nuclei per area). The gene discussed is RBFOX3; the disease is Alzheimer disease.