UNC5C and Alzheimer disease: Early changes included upregulation of cellular adhesion molecules (CADM1, CDRH3, PCDHGA1, PCDHB14, PCDHB16, CLSTN1, ITGA6, NEO1, ANOS1) and neuronal guidance cues (NLGN3, NTRK3, SEMA4B, NTNG2), signaling receptors (PTCHD1, NRP1, BMPR2, UNC5C)70 and GFAP, a known hallmark of AD and astrogliosis71 (Fig. 6j, top).