KLF2 and cerebral cavernous malformation: Functional studies have shown that CCM-associated cardiovascular defects can be suppressed when CCM-deficient mice undergo a loss of Klf2/4 (Zhou et al, 2015, 2016; Cuttano et al, 2016) or zebrafish ccm mutants lack Klf2a/b (Renz et al, 2015).