Additionally, infection with periodontal pathogen P. gingivalis can also induce the expression of aCL in mouse serum.115 The induction of aCL expression by microorganisms is achieved through the molecular mimicry of β2 glycoprotein I. Apart from P. gingivalis, both A. actinomycetemcomitans and Treponema denticola (T. denticola) possess sequences homologous to β2GPI,62,116 which elucidates the promotion effect of periodontitis on aCL expression. This evidence concerns the gene ACLY and infection.