ACLY and autoimmune polyendocrinopathy: Anticardiolipin antibodies, also named as anticardiolipin (aCL), are one of the key markers used in laboratory examinations to diagnose APS.109 In systemically healthy individuals with periodontitis, approximately 15% to 20% have higher aCL serum levels than 95% of the general population or healthy individuals without periodontitis.114 This observation suggested a possible relationship between periodontitis and APS.