Further, we replicated the association between amyotrophic lateral sclerosis and C9orf72 (rTWAS and joint Z = 5.4, rTWAS and joint P = 6.8 x 10-8, rTWAS Bonferroni P = 5.49 x 10-4, PIP = 1.0), one of the most well-known genetic risk factors for this condition. Here, C9orf72 is linked to amyotrophic lateral sclerosis.