CD8A and neoplasm: In addition, the DIR NP with laser irradiation was more effective on inducing DC activation in primary tumors (1.4‐fold) and tumor drainage lymph nodes (1.6‐fold) compared with native R848, eventually resulting in a higher infiltration of CD8+ T cells in tumors and whole‐body immune response for distant tumor (inhibition rate: 80.4%) and lung metastasis inhibition.