A previous study identified SPOP as the specific cytoplasmic E3 ubiquitin ligase of PrLZ and Cdc20.[39, 40] Interestingly, SPOP was also found to be a bona fide FZR1 substrate.[41] This finding led us to identify which APC mediates the regulation of PrLZ ubiquitination and investigate the regulatory mechanism linking these proteins in prostate cancer. Here, APC is linked to prostate cancer.