A previous study identified SPOP as the specific cytoplasmic E3 ubiquitin ligase of PrLZ and Cdc20.[39, 40] Interestingly, SPOP was also found to be a bona fide FZR1 substrate.[41] This finding led us to identify which APC mediates the regulation of PrLZ ubiquitination and investigate the regulatory mechanism linking these proteins in prostate cancer. The gene discussed is FZR1; the disease is Familial prostate cancer.