To determine whether Tpd52 knockout accelerates tumorigenesis in vivo, we established a two‐step chemical carcinogen (7,12‐dimethylbenz[a]anthracene (DMBA) followed by 12‐O‐tetradecanoyl phorbol‐13‐acetate (TPA))‐induced skin tumor model as described previously.[27] Compared with WT mice, Tpd52−/− mice displayed a higher incidence of skin tumors and increased papilloma burden (Figure 3e,f). The gene discussed is TPD52; the disease is skin neoplasm.