The microsatellite status was available for 697 patients with multi-hit PIK3CA CRC, of which 17.65% (123/697) were microsatellite instability-high (MSI-high) compared to 3.46% (1119/32,335) of wild-type PIK3CA CRC (P < .001). This evidence concerns the gene PIK3CA and colorectal carcinoma.