The phosphatidylinositol 3-kinase (PI3K) pathway is one that is central to cell survival, proliferation, and growth regulation and is commonly dysregulated solid tumor malignancies.14,15 An activating mutation in the PIK3CA oncogene is detected in approximately 20% of patients living with colorectal cancer (CRC).16PIK3CA codes for the catalytic subunit, p110⍺, of the phosphoinositide 3-kinase (PI3K) complex, which ultimately activates the serine/threonine protein kinase B (AKT) and mammalian target of rapamycin (mTOR) signaling pathway. The gene discussed is PIK3CA; the disease is colorectal carcinoma.