IL1R1 and atopic eczema: Macrophage-secretedIL-1α and CXCL2 (ligand for IL-1R and CXCR2, respectively) havebeen demonstrated to drive the DC cluster formation and migration,which are essential for complete elicitation of local T cell responsesand inflammation in CHS skin.28 LTB4 eicosanoid,converted from LTA4 by the Zn-dependent enzyme LTA4H, fuels neutrophilrecruitment to the skin in allergic dermatitis.29 Our data point to the possibility that nZnO may cause defectsin the IL-1R-, CXCR2-, and LTB4-mediated signaling pathways, therebyimpeding leukocyte migration and thwarting contact allergic responses.