LYST and granular corneal dystrophy type II: It is estimated that CHS affects 15–20% of the globalpopulation.3 Common signs and symptomsof ACD include varying degrees of skin redness, itching, swelling,and blister at the site of inflammation.4 The CHS immune response is divided into two phases: the sensitizationphase and the elicitation or challenge phase.5 During the sensitization phase, a low-molecular-weight moleculetermed hapten acts as a sensitizer that penetrates skin and becomesimmunogenic once it is covalently bound to a carrier molecule suchas skin protein.