IFIH1 and viral infectious disease: To determine the contribution of MDA5 to induction of IFN1s response in fish upon viral infection, we have engineered a stable cell line derived from Chinook salmon Oncorhynchus tshawytscha with a ifih1 gene invalidated by targeted mutation using CRISPR/Cas9 genome editing and have characterised its ability to induce IFN1s and to resist to viral infection.