Our study demonstrated significantly elevated levels of NEAT1 in OXP-resistant cells compared to parental cells, consistent with previous findings in other types of cancer This study may be the first to demonstrate the association of NEAT1 with OXP-resistance in CRC cells and to identify its exosomal form in isolated exosomes, which could potentially serve as a biomarker. This evidence concerns the gene NEAT1 and colorectal carcinoma.