Current research employed siRNA reagents to repress VMN SF-1 gene expression in vivo to address the premise that in female rat Ghrh neurons, SF-1 controls eu- and/or hypoglycemia-associated expression patterns of gene transcripts that generate counterregulatory neurotransmitter biosynthetic pathway, AMPK catalytic subunit, and ER variant proteins. The gene discussed is GHRH; the disease is Hypoglycemia.