There was no difference in the amount of atherosclerosis at the level of the aortic sinus (data not shown), but IR+/−/ApoE−/−/Nox2−/y mice had evidence of elastin breaks at the level of the aortic sinus, which was less prevalent in IR+/−/ApoE−/−/Nox2+/y (Fig. 2H). Here, APOE is linked to atherosclerosis.