A study by Miwa et al., in 2012, showed that AKT–mTOR–p70 S6K, extracellular signal-regulated kinases (ERK), and NF-κB were involved together in proliferation of osteosarcoma cells and these pathways could be inhibited by caffeine thereby decreasing tumor burden (Miwa et al., 2012). This evidence concerns the gene NFKB1 and neoplasm.