JAG1 has previously been shown to induce survival and proliferation of human mesenchymal stem cells, which are osteoblast precursors and various other human cell types, for example LNCaP which is a prostate cancer cell line, glioma cells, and intestinal epithelial cells during progression of colorectal cancer (Pannequin et al., 2009; Purow et al., 2005). Here, JAG1 is linked to Familial prostate cancer.