Small cell lung cancer (SCLC) showed high enhancer of zeste homolog 2 (EZH2) expression and promoted epithelial‐mesenchymal transition (EMT), and miR‐4448 prevented EZH2‐mediated EMT and tumorigenesis by modulating the Girdin/Akt/AMP‐activated protein kinase axis. The gene discussed is CCDC88A; the disease is small cell lung carcinoma.