To screen the interrelationship between sepsis and disulfidptosis, we first extracted disulfidptosis‐related genes from the latest literature and filtered out five upregulated genes (FLNA, LRPPRC, SLC7A11, NUBPL and RPN1) and seven downregulated genes (GLUT, GYS1, MYH9, NCKAP1, NDUFS1, SLC3A2 and TLN1) showed the differential expression between sepsis and disulfidptosis (Figure 3A). The gene discussed is RPN1; the disease is Sepsis.