HES1 and central nervous system cancer: As such, cells that responded to 2OHOA (U- 87 MG, SF-268, U-118 MG, SF-295 and U-251 MG) had a higher reduction of the HES1 mRNA levels upon 2OHOA treatment in comparison with other glioma cell lines (SNB-19 MG, SNB-75 MG) with resistance to the bioactive molecule, indicating the relevance of this gene in the effect of 2OHOA.