By contrast, there was no reduction in HES1 mRNA levels in cells that did not respond to 2OHOA (IC50 ≥ 600 μM: SNB-19, 138.30% ± 18.85; SNB-75, 99.59% ± 8.51), suggesting the relevance of this gene in the effects of 2OHOA on GBM (Fig. 1b, Table S1b). Here, HES1 is linked to glioblastoma.