Finally, the third case (#8, clinical features consistent with a PSP-like phenotype and positive anti-IgLON5 antibodies), presented typical distribution of the anti-IgLON5 disease-related tau pathology with mainly neuronal tau pathology, which was, however, dominated by 4R tau isoforms, and showed no astrocytic tau pathology definitory of any other known 4R tauopathy. This evidence concerns the gene MAPT and tauopathy.