These findings also support the notion that the accumulation of misfolded tau in the CNS likely represents a delayed, secondary phenomenon, as it also occurs in subacute sclerosing panencephalitis (SSPE) [6], postencephalitic parkinsonism (PEP) [11], chronic traumatic encephalopathy (CTE) [37], and likely in Guam PDC (Parkinson-dementia complex) and the Nodding syndrome [42]. Here, MAPT is linked to subacute sclerosing panencephalitis.