The co-accumulation of tau and TDP-43 proteins is increasingly recognized in some tauopathies, like chronic traumatic encephalopathy or SSPE (also considered a “secondary” tauopathies) [1, 36, 41], or some primary astrogliopathies [16, 24, 32]. The gene discussed is TARDBP; the disease is subacute sclerosing panencephalitis.