IGLON5 and supranuclear palsy, progressive, 1: Finally, the third case (#8, clinical features consistent with a PSP-like phenotype and positive anti-IgLON5 antibodies), presented typical distribution of the anti-IgLON5 disease-related tau pathology with mainly neuronal tau pathology, which was, however, dominated by 4R tau isoforms, and showed no astrocytic tau pathology definitory of any other known 4R tauopathy.