Another patient with a long disease duration who had been retrospectively identified, had neuropathological features that were formally consistent with a diagnosis of PSP, including neuronal and glial tau pathology with some, but not many, typical tufted astrocytes in the basal ganglia, but a predominant and severe brainstem involvement [8, 47], suggesting a brainstem variant of PSP. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.