MMP9 and neoplasm: In contrast, highly expressed marker genes for domain 2 were therapeutic targets for related human malignancies, such as MMP9 (Augoff et al. 2022, Tufaro et al. 2011), CXCL10 (Liu et al. 2011), and CXCL9 (Ding et al. 2016), suggesting that domain 2 is a relatively severe tumor region (Fig. 4e).