TNF‐α, IL‐1 and IL‐6 levels were increased in the CLP group than the sham group (Figure 3F–H; (F: interaction: CLP× Yapf/f, F = 7.584, p = 0.0048; CLP: F = 15.684, p < 0.0001; Yapf/f: F = 3.954, p = 0.0198); (G: interaction: CLP× Yapf/f, F = 8.214, p = 0.0043; CLP: F = 12.654, p < 0.0001; Yapf/f: F = 4.526, p = 0.0215); (H: interaction: CLP× Yapf/f, F = 6.954, p = 0.0068; CLP: F = 15.214, p < 0.0001; Yapf/f: F = 4.102, p = 0.0301)), indicating that inflammatory factors induced by sepsis infiltrate the hippocampus. The gene discussed is IL1B; the disease is Sepsis.