YAP1 and Sepsis: In OFT, mice spent less time in the central area in the CLP group, and even less time after Yap1 conditional knockout (Figure 1J (interaction: CLP× Yapf/f, F = 8.584, p = 0.0029; CLP: F = 12.542, p < 0.0001; Yapf/f: F = 2.984, p = 0.0436)), indicating that sepsis could cause emotional disorders in mice, and that Yap1 knockout could exacerbate these behavioural deficits.