SIM2 and cancer: We used SUM159 cells as a model system, as they do not express basal levels of SIM2, allowing us to overexpress SIM2 to investigate its functional roles in cancer (Kwak et al., 2007; Sanchez et al., 2023; Scribner et al., 2013; Wall et al., 2023; Wyatt et al., 2019).