Moreover, in the context of antagonist protocols, the use of GnRH agonist trigger was the preferred option if there are ≥18 follicles ≥11 mm as a predictor of severe OHSS or if the estradiol level is ≥5,000 ng/ml and this procedure should be systematically followed by a freeze-all according to respondents. The gene discussed is GNRH1; the disease is ovarian hyperstimulation syndrome.