Our results confirm the separate mechanism of regulation of this cadherin achieved by inhibition of CHI3L1 in our studies, suggesting that highest concentration of G721–0282 leads to a reduction of N-cadherin expression in our spheroid model of GBM at the protein level in immunoblotting and immunohistochemical reaction as well as at the mRNA level. This evidence concerns the gene CDH2 and glioblastoma.